US researchers say they have identified how a high-fat diet interferes with the body's sugar sensors and triggers type 2 diabetes....
The authors argue that a deeper understanding of the processes involved could help them develop a cure. One of the main risk factors for type 2 diabetes is being overweight -- rising obesity levels have contributed to a doubling of diabetes cases in the last 30 years.
Sugar in the blood is monitored by pancreatic beta cells. If sugar levels are too high then the cells release the hormone insulin, which tells the body to bring the levels back down. Key to this is the enzyme GnT-4a. It allows the cells to absorb glucose and therefore know how much is in the blood.
Researchers at the University of California and the Sanford-Burnham Medical Research Institute say they have shown how fat disrupts the enzyme's production. Experiments on mice showed that those on a high-fat diet had elevated levels of free fatty acids in the blood. These fatty acids interfered with two proteins - FOXA2 and HNF1A - involved in the production of GnT-4a. The result: fat effectively blinded cells to sugar levels in the blood and the mice showed several symptoms of type 2 diabetes. The same process also took place in samples of human pancreatic cells.
Lead researcher Dr. Jamey Marth said, "The observation that beta cell malfunction significantly contributes to multiple disease signs, including insulin resistance, was unexpected."
He suggested that boosting GnT-4a levels could prevent the onset of type 2 diabetes: "The identification of the molecular players in this pathway to diabetes suggests new therapeutic targets and approaches towards developing an effective preventative or perhaps curative treatment." "This may be accomplished by beta cell gene therapy or by drugs that interfere with this pathway in order to maintain normal beta cell function."
Dr. Iain Frame, Director of Research at Diabetes UK, said, "The researchers have linked their results in mice to the same pathways in humans and although they did not show they could prevent or cure type 2 diabetes, they have shown it is a theory worth investigating further."
"We will watch this with great interest and hope this early work will eventually lead to some benefit to people with type 2 diabetes."
Showing posts with label diabetes and insulin. Show all posts
Showing posts with label diabetes and insulin. Show all posts
Wednesday, August 31, 2011
Sunday, March 20, 2011
Insulin and Weight Gain?
Q: I take insulin and it's very hard for me to lose weight. I've read that this can happen — that insulin can contribute to weight gain. What can I do? I try to watch what I eat and have recently joined a fitness club, but I haven't had much success yet. Any advice?
— Susan
A:Insulin can, in fact, lead to weight gain. Here's how it works:
Insulin is a potent hormone that regulates glucose, fat, and protein metabolism. In many cases, people with type 2 diabetes start insulin therapy when oral medicines cannot or no longer control their glucose levels. This means that blood glucose levels in the body have been elevated for an extended period of time. In this state, the body does not metabolize glucose, fat, or protein in a well-regulated or efficient way. Cells that require glucose to function properly begin starving because of inadequate amounts of circulating insulin. Fat metabolism becomes abnormal, which can lead to high triglyceride levels. The body's metabolic rate then increases as it tries to convert this fat into a source of energy.
These abnormalities are usually corrected when you begin insulin therapy. The body begins using glucose better, and the metabolic rate declines by about five percent. Insulin also helps the body gain fat-free mass, but on the flip side, it also helps it store fat more efficiently. Therefore, efficient glucose and fat metabolism and the reduction in metabolic rate cause most people to gain four to six pounds during the first two to three years of insulin therapy. Individuals who had poor glucose control, or who lost significant amounts of weight before beginning insulin treatment, usually experience the most weight gain.
Losing weight in general requires persistent attention to energy balance — that is, the number of calories you take in versus the number you burn. During insulin therapy, the body does not need as much food to get the energy it requires, so reducing your caloric intake is quite important. This should be accompanied by an exercise regimen, as you have begun, to expend at least 200 to 300 calories a day.
In addition, you should consult with your doctor to consider other kinds of diabetes treatments that could mitigate the weight gain. These include metformin, an oral medication that prevents weight gain; an insulin analogue called detemir, which has been shown to cause less weight gain than NPH insulin; and exenatide, an antidiabetes injection that can lead to weight loss.
— Susan
A:Insulin can, in fact, lead to weight gain. Here's how it works:
Insulin is a potent hormone that regulates glucose, fat, and protein metabolism. In many cases, people with type 2 diabetes start insulin therapy when oral medicines cannot or no longer control their glucose levels. This means that blood glucose levels in the body have been elevated for an extended period of time. In this state, the body does not metabolize glucose, fat, or protein in a well-regulated or efficient way. Cells that require glucose to function properly begin starving because of inadequate amounts of circulating insulin. Fat metabolism becomes abnormal, which can lead to high triglyceride levels. The body's metabolic rate then increases as it tries to convert this fat into a source of energy.
These abnormalities are usually corrected when you begin insulin therapy. The body begins using glucose better, and the metabolic rate declines by about five percent. Insulin also helps the body gain fat-free mass, but on the flip side, it also helps it store fat more efficiently. Therefore, efficient glucose and fat metabolism and the reduction in metabolic rate cause most people to gain four to six pounds during the first two to three years of insulin therapy. Individuals who had poor glucose control, or who lost significant amounts of weight before beginning insulin treatment, usually experience the most weight gain.
Losing weight in general requires persistent attention to energy balance — that is, the number of calories you take in versus the number you burn. During insulin therapy, the body does not need as much food to get the energy it requires, so reducing your caloric intake is quite important. This should be accompanied by an exercise regimen, as you have begun, to expend at least 200 to 300 calories a day.
In addition, you should consult with your doctor to consider other kinds of diabetes treatments that could mitigate the weight gain. These include metformin, an oral medication that prevents weight gain; an insulin analogue called detemir, which has been shown to cause less weight gain than NPH insulin; and exenatide, an antidiabetes injection that can lead to weight loss.
Wednesday, March 16, 2011
Healthy Snacking With Type 2 Diabetes
You might not have to forgo that afternoon snack if you have type 2 diabetes, but you may have to change what you eat.
Having a quick bite to eat in the afternoon or before bed is a habit many people might not think twice about. However, after someone is diagnosed with type 2 diabetes, it seems like every eating habit gets scrutinized, including snacks. Since adjusting lifestyle factors like diet and exercise are among the first steps in managing type 2 diabetes, snacking in a healthy and controlled way can help manage the disease.
Living with Type 2 Diabetes: Should I Snack?
Not everyone with type 2 diabetes should snack regularly. Snacking patterns should be tailored to an individual’s preferences, schedule, and medication. For example, someone taking insulin can use a snack to help prevent a drop in blood sugar between meals. Someone else might have a snack while preparing dinner, to relieve hunger and keep from overeating before dinner is ready. Snacking in general can help spread out food intake over the course of a day, helping to lower blood lipids and glucose for people with type 2 diabetes.
Living with Type 2 Diabetes: Choosing the Right Snack
Choosing the right snack along with the right scheduling is equally important. Here are some tips for selecting that perfect snack:
Choose quality. Lorena Drago, MS, a registered dietitian and diabetes educator with the American Association of Diabetes Educators, has a catchy way to remember the important criteria for a good snack: “I tell my patients to mind their Ps and Qs — P stands for portion and Q for quality.” Keeping snack portion sizes small is important, but so is choosing quality, healthy snacks. For example, three crackers with one slice of cheese is a better-quality snack than a chocolate bar.Get educated. Educate yourself about basic nutrition components like carbohydrates, fat, and protein so that you are comfortable reading nutrition labels. Drago advises choosing snacks with “staying power,” those that will prevent you from eating too much later in the day. Drago recommends snacks with some fat and some protein, to slow food absorption and keep you feeling full longer. Stay away from foods heavy in carbohydrates, like sugary desserts.Plan ahead. Plan snacks in advance to make sure healthy choices are available and to prevent overeating. Living with Type 2 Diabetes: The Dark Side of Snacking
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Snacking can work against you if you take it too far. Thomas Wolever, MD, PhD, professor of nutritional sciences at the University of Toronto, says that research shows that when people with type 2 diabetes eat six meals a day, instead of three, they tend to overeat and, in turn, gain weight, which overcomes any potential benefit of managing blood glucose and lipids.
Since weight control is often a primary concern for people with type 2 diabetes, snacking carefully and strategically is very important. Some diabetics may have a hard time stopping after eating one handful of tasty cashews — a tightly restricted eating schedule might work better for these people.
People with type 2 diabetes should examine their own lifestyle, personality, and medication before deciding whether snacking is a healthy approach for tackling their diabetes. Diabetes educators can help you make these decisions and offer suggestions for how to fit different approaches into your lifestyle. The best snacking pattern for you is a custom plan that will fit comfortably into your lifestyle and help keep your type 2 diabetes under control.
Having a quick bite to eat in the afternoon or before bed is a habit many people might not think twice about. However, after someone is diagnosed with type 2 diabetes, it seems like every eating habit gets scrutinized, including snacks. Since adjusting lifestyle factors like diet and exercise are among the first steps in managing type 2 diabetes, snacking in a healthy and controlled way can help manage the disease.
Living with Type 2 Diabetes: Should I Snack?
Not everyone with type 2 diabetes should snack regularly. Snacking patterns should be tailored to an individual’s preferences, schedule, and medication. For example, someone taking insulin can use a snack to help prevent a drop in blood sugar between meals. Someone else might have a snack while preparing dinner, to relieve hunger and keep from overeating before dinner is ready. Snacking in general can help spread out food intake over the course of a day, helping to lower blood lipids and glucose for people with type 2 diabetes.
Living with Type 2 Diabetes: Choosing the Right Snack
Choosing the right snack along with the right scheduling is equally important. Here are some tips for selecting that perfect snack:
Choose quality. Lorena Drago, MS, a registered dietitian and diabetes educator with the American Association of Diabetes Educators, has a catchy way to remember the important criteria for a good snack: “I tell my patients to mind their Ps and Qs — P stands for portion and Q for quality.” Keeping snack portion sizes small is important, but so is choosing quality, healthy snacks. For example, three crackers with one slice of cheese is a better-quality snack than a chocolate bar.Get educated. Educate yourself about basic nutrition components like carbohydrates, fat, and protein so that you are comfortable reading nutrition labels. Drago advises choosing snacks with “staying power,” those that will prevent you from eating too much later in the day. Drago recommends snacks with some fat and some protein, to slow food absorption and keep you feeling full longer. Stay away from foods heavy in carbohydrates, like sugary desserts.Plan ahead. Plan snacks in advance to make sure healthy choices are available and to prevent overeating. Living with Type 2 Diabetes: The Dark Side of Snacking
There's more content below this advertisement. Jump to the content.
Snacking can work against you if you take it too far. Thomas Wolever, MD, PhD, professor of nutritional sciences at the University of Toronto, says that research shows that when people with type 2 diabetes eat six meals a day, instead of three, they tend to overeat and, in turn, gain weight, which overcomes any potential benefit of managing blood glucose and lipids.
Since weight control is often a primary concern for people with type 2 diabetes, snacking carefully and strategically is very important. Some diabetics may have a hard time stopping after eating one handful of tasty cashews — a tightly restricted eating schedule might work better for these people.
People with type 2 diabetes should examine their own lifestyle, personality, and medication before deciding whether snacking is a healthy approach for tackling their diabetes. Diabetes educators can help you make these decisions and offer suggestions for how to fit different approaches into your lifestyle. The best snacking pattern for you is a custom plan that will fit comfortably into your lifestyle and help keep your type 2 diabetes under control.
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